A facile synthesis of 5-Iodo-6-substituted Pyrimidines from Uracil-6-Carboxylic acid (Orotic acid)
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چکیده
منابع مشابه
Biological Studies of Analogs of Orotic Acid : 6—Uracil sulfonic Acid, 6-Uracilsulfonamide, and 6-Uracil Methyl Sulfone * WILLIAM L. HOLMES AND ARNOLD D. WELCH
Investigations of the metabolism of orotic acid have shown that this compound is utilized by cer thin bacteria (@O)and by the mammal for the syn thesis of pentosenucleic acid (1, 5). Although it has not been definitely established that orotic acid (or a metabolic derivative of it) is an obligatory inter mediate in the biosynthesis of nucleic acids, there is considerable evidence in support of t...
متن کاملImproved synthesis of N1-substituted orotic acid derivatives.
An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single 15N label at either N-1 or N-3.
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It was demonstrated by Richardson in 1936 (1) that uracil and guanine were essential for the growth of certain bacteria. Later several investigators found that purines and pyrimidines and corresponding nucleotides are of importance for the metabolism of different microorganisms. Snell and Mitchell (2) established the fact that guanine, adenine, uracil, and thymine may be limiting factors of gro...
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In recent years erotic acid (uracil-4-carboxylic acid) has been found to be essential for the growth of some microorganisms;l some pyrimidine-requiring Neurospora mutants were found to grow equally well with uracil and erotic acid2 and some mutants have been found to produce erotic acid.3 It has been suggested that erotic acid is a by-product in the biosynthesis of pyrimidines in Neurospora.s I...
متن کامل6-Fluoro-4-oxochroman-2-carboxylic acid
The title compound, C(10)H(7)FO(4), is an inter-mediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione. The di-hydro-pyran-one ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the mol-ecules are linked into zigzag chains along [100] by O-H⋯O hydrogen bonds and C-H⋯π inter-...
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ژورنال
عنوان ژورنال: Dhaka University Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 1816-1839,1816-1820
DOI: 10.3329/dujps.v12i2.17613